Kev hloov kho Methylation

Methylation-hloov peptides kuj hu ua methylation-paub peptides. Kev hloov kho methylation yog tom qab-kev txhais lus kho kom zoo nkauj ntawm cov proteins (PTMs) Yuav luag tag nrho cov txheej txheem hauv lub neej yog koom nrog hauv cov hlwb thiab ua lub luag haujlwm tseem ceeb. Proteins hloov hydroxyl pawg mus rau cov amino acid residues rau covalent bonding nyob rau hauv lub catalysis ntawm methyltransferases. Methylation yog cov txheej txheem hloov pauv hloov pauv tau catalyzed los ntawm demethylase.

Kev tshawb fawb qhia tau hais tias feem ntau methylation / Lub demethylated amino acid feem ntau yog lysine (Lys) thiab arginine (Arg) Kev tshawb fawb pom tias histone lysine methylation hloov kho muaj ntau yam kev lom neeg xws li qia cell tu thiab faib. ＸChromosome inactivation, transcriptional regulation thiab ＤＮＡInjury response, etc., feem ntau cuam tshuam rau chromatin condensation thiab inhibits gene qhia. Histone arginine methylation plays lub luag haujlwm tseem ceeb hauv kev tswj hwm ntawm noob caj noob ces thiab tuaj yeem cuam tshuam ntau yam txheej txheem physiological ntawm cov hlwb, suav nrog DNA kho, teeb liab hloov, kev loj hlob ntawm tes, thiab carcinogenesis. Yog li ntawd, Source Peptide Biotech tau tsim tshwj xeeb tsim methyl-decorated peptide thev naus laus zis los hloov cov protein tom qab kev txhais lus (PTMS) Pab nrog kev tshawb fawb.

Siv zoo Fmoc-Lys(Me,Boc)-OH, Fmoc-Lys(Me2)-OH, Fmoc-Lys(Me3)-OH.HCL, Fmoc-Arg(Me,Pbf)- Fmoc-Arg(me)2-OH.HCl(asymmetrical), Fmoc-Arg(me)2-OH.HCl(symmetrical) thiab lwm yam raw khoom, siv Fmoc synthesized by solid phase synthesis process kom tau Lys methylation, Arg For methylation-tagged LC. Cov khoom kawg muab cov khoom loj sib xws thiab kev tsom xam purity. HPLC chromatogram, thiab COA.