Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 1245732-48-2 mipsagargin hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 1245732-48-2 mipsagargin los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS 1245732-48-2 Mipsagargin Nr |
| Tshuaj npe | (2S)-2-[[(4S)-4-[[[(4S)-4-[[(4S)-4-[[(2S)-4-[[12-[[(3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-ac ethyloxy-3,3a-dihydroxy-3,6,9-trimethyl-8-[(Z)-2-methylbut-2-enoyl]oxy-7-octanoyloxy-2-oxo-4,5 ,6a,7,8,9b-hexahydroazuleno[4,5-b]furan-4-yl]oxy]-12-oxododecyl]amino]-2-amino-4-oxobutanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-4-penanoyl]caraminoyl] kua qaub |
| Purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₆₆H₁₀₀N₆O₂₇ |
| Molecular Luj (Da) | 1409.52 |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | Cov khoom vaj khoom tsev | Daim ntawv ntsev |
| Mipsagargin | Mipsagargin; G-202; CAS 1245732-48-2; PSMA-targeted prodrug | PSMA- phiaj xwm PDC, SERCA twj tso kua mis inhibitor, ER kev ntxhov siab induction, Kev tshawb fawb qog nqaij hlav, kev tshawb fawb qog nqaij hlav qog nqaij hlav, Vascular -targeted antitumor | Polyglutamate peptide conjugated rau thapsigargin analog 12-ADT, PSMA-cleavable prodrug | C₆₆H₁₀₀N₆O₂₇ | 1408.66 | 1409.52 | Peptide-Drug Conjugate (PDC) | Dawb puag |
Physicochemical Solubility & Cia Parameters
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Amino Acid Tag Nrho Lub Npe Sequence | Molecular Formula | Qhov hnyav Molecular (Da) | Qhov Nruab Nrab Molecular Luj (Da) | Cov khoom vaj khoom tsev | Daim ntawv ntsev |
| Mipsagargin | Mipsagargin; G-202; CAS 1245732-48-2; PSMA-targeted prodrug | PSMA- phiaj xwm PDC, SERCA twj tso kua mis inhibitor, ER kev ntxhov siab induction, Kev tshawb fawb qog nqaij hlav, kev tshawb fawb qog nqaij hlav qog nqaij hlav, Vascular -targeted antitumor | Polyglutamate peptide conjugated rau thapsigargin analog 12-ADT, PSMA-cleavable prodrug | C₆₆H₁₀₀N₆O₂₇ | 1408.66 | 1409.52 | Peptide-Drug Conjugate (PDC) | Dawb puag |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Hom phiaj / Receptor |
| PDC-MIP001 | PSMA-activated peptide-cov tshuaj conjugate prodrug uas xa cov thapsigargin analog rau cov qog, inhibits SERCA twj tso kua mis kom induce apoptosis, siv nyob rau hauv prostate cancer thiab cov qog nqaij hlav. | Mipsagargin (kev loj hlob code G-202) yog thawj qhov chaw kho mob-theem PSMA-targeted peptide-tshuaj conjugate prodrug, muaj xws li PSMA- tshwj xeeb polyglutamate peptide substrate conjugated rau} gin 12 ADER thiab CA cov tshuaj analog Tps {9 twj tso kua mis inhibitor. Cov tshuaj nws tus kheej tsis yog -cytotoxic. Thaum mus txog cov qog nqaij hlav, nws yog hydrolyzed los ntawm prostate-specific membrane antigen (PSMA), uas tau nthuav tawm heev ntawm cov qog nqaij hlav qog nqaij hlav prostate thiab qog neovascular endothelial hlwb, tso tawm cov metabolite 12-ADT. 12-ADT tshwj xeeb khi thiab inhibits sarcoplasmic ⁰At-sarcoplasmic ²-endopum. (SERCA) twj tso kua mis, cuam tshuam endoplasmic reticulum calcium homeostasis, ua rau muaj kev ntxhov siab ER thiab thaum kawg inducing apoptosis ntawm cov qog hlwb thiab qog vascular endothelial hlwb. Piv nrog dawb thapsigargin, nws ua tiav qhov kev txhim kho qog nqaij hlav thiab txo cov kab mob toxicity. Nws tau ua tiav Phase II kev sim tshuaj rau ntau yam qog nqaij hlav xws li mob qog noj ntshav prostate, hepatocellular carcinoma thiab glioblastoma, thiab ua haujlwm ua cov cuab yeej tseem ceeb molecule rau phiaj xwm antitumor PDC txoj kev loj hlob thiab qog vascular targeting kev tshawb fawb. | Kev tshawb fawb tshuaj kho mob qog noj ntshav, kev tshawb fawb txog qog nqaij hlav qog nqaij hlav, kev tshawb fawb txog kab mob qog nqaij hlav, Peptide -tshuaj kho kev txhim kho, ER kev tshawb fawb txog kev ntxhov siab, qog vascular phiaj kho mob | Sarco/Endoplasmic Reticulum Ca²⁺-ATPase (SERCA twj tso kua mis); Prostate-Specific Membrane Antigen (PSMA, ua kom lub hom phiaj); ER txoj kev nyuaj siab apoptosis |
Cim npe nrov: CAS 1245732-48-2 mipsagargin, Tuam Tshoj cas 1245732-48-2 mipsagargin manufacturers, lwm tus, Hoobkas
