Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 251562-00-2 tifuvirtide hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 251562-00-2 tifuvirtide los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 251562-00-2: Tifuvirtide |
| Kev piav qhia | Tifuvirtide (kev loj hlob code T-1249) yog thib ob- tiam HIV-1 fusion inhibitor, 39-amino acid hluavtaws hybrid peptide. Nws thaiv cov membrane fusion los ntawm kev khi rau HR1 domain ntawm tus kab mob gp41, thiab tseem ua haujlwm tawm tsam enfuvirtide (T20)-resistant cais. Nws yog siv rau hauv kev kis kab mob HIV thiab kev tshawb fawb tshuaj tiv thaiv kab mob. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Cov mis mos molecular | C₂₃₅H₃₄₁N₅₇O₆₇ |
| Molecular Luj (Da) | 5036.55 |
| Terminal kev hloov kho | N-terminal acetylation, C-terminal amidation |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Tifuvirtide | Tifuvirtide; T-1249; CAS 251562-00-2; Thib ob tiam HIV fusion inhibitor | HIV -1 fusion inhibition, Antiviral peptide, Membrane fusion blockade, gp41 targeting, Kev tshawb fawb tshuaj tiv thaiv kab mob, Tshuaj tua kab mob | N-acetyl-tryptophan-glutamine-glutamic acid-tryptophan-glutamic acid-glutamine-lysine-isoleucine-threonine-alanine{11}}leucine-leucine-glutamic acid-glutamine-alanine-glutamine-isoleucine-glutamine-glutamine-glutamic acid-lysine-asparagine{{23}{2}glutamic acid{2} acid-leucine-glutamine-lysine-leucine-aspartic acid-lysine-tryptophan-alanine-serine-leucine{7}{3}glutamic{36} acid-tryptophan-phenylalanamide | C₂₃₅H₃₄₁N₅₇O₆₇ | 5033.51 | 5036.55 | Acetylation | Amidation | 39 |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-TIF001 | hmoov dawb | Khaws ntawm -20℃, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; tsis txhob rov qab khov-thaw mus, oxidation thiab lub teeb muaj zog | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; npaj cov kev daws teeb meem pom zoo kom npaj rau hauv tsis muaj zog acidic tsis thiab khaws cia ntawm -80℃hauv aliquots | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 6 lub hlis ntawm -80℃hauv aliquots; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Kev txwv dej solubility, npaj hauv pH 4-6 tsis muaj zog acidic tsis muaj zog, me me ntawm DMSO tuaj yeem ntxiv rau solubilization **. Muaj ntau yam tryptophan residues ua rau photooxidation. Kev tiv thaiv lub teeb nruj thiab tsis txhob raug huab cua ntev | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-TIF001 | Thib ob- tiam HIV-1 fusion inhibitor, 39-amino acid hybrid peptide, blocks gp41 rau-helix bundle tsim, nquag tawm tsam enfuvirtide-resistant cais | Tifuvirtide (T-1249) yog tus thib ob- tiam neeg hluavtaws peptide HIV-1 fusion inhibitor. Nws cov txheej txheem tseem ceeb suav nrog kev khaws cia HR2 thaj tsam ntawm gp41 los ntawm HIV-1, HIV-2 thiab simian immunodeficiency virus (SIV), thiab muaj ob qho tib si N-terminal PBD domain thiab C-terminal tryptophan-kev ua kom muaj txiaj ntsig zoo nrog rau cov kab mob zoo dua qub piv rau thawj tiam enfuvirtide (T20). Nws sib tw khi rau HR1 tus thawj tswj hwm ntawm tus kab mob transmembrane glycoprotein gp41, tiv thaiv kev tsim ntawm HR1 / HR2 rau-helix bundle conformation, yog li thaiv fusion ntawm viral hnab ntawv nrog tus tswv tsev cell membrane thiab inhibiting viral nkag. Siv tau zoo tiv thaiv ntau hom kab mob HIV-1 thiab khaws cia muaj zog inhibitory kev ua haujlwm tawm tsam feem ntau enfuvirtide-resistant cais tawm, nws ua haujlwm raws li cov cuab yeej tseem ceeb molecule rau HIV nkag mechanism kev tshawb fawb, tshuaj tiv thaiv kab mob, thiab tshiab fusion inhibitor tshuaj ntsuam xyuas thiab kev loj hlob. | Kev tshawb fawb txog kab mob, kev tshawb fawb txog kab mob HIV, kev txhim kho tshuaj tiv thaiv kab mob, Kev tshawb fawb Membrane fusion mechanism, Tshuaj-kev tshawb nrhiav kab mob tiv thaiv, Kev tshawb fawb tshuaj tua kab mob | HIV gp41 HR1 domain; Kab mob-cell membrane fusion txoj kev; Rau -helix bundle formation inhibition |
Cim npe nrov: CAS 251562-00-2 tifuvirtide, Tuam Tshoj cas 251562-00-2 tifuvirtide manufacturers, lwm tus, Hoobkas
