Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm cas 604802-70-2 epoetin zeta hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau cov lag luam wholesale bulk zoo cas 604802-70-2 epoetin zeta los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 604802-70-2: Epoetin zeta |
| Kev piav qhia | Epoetin zeta yog biosimilar ntawm recombinant human erythropoietin (rhEPO). Nws tshwj xeeb activates EPO receptors ntawm erythroid progenitor hlwb los txhawb erythrocyte proliferation thiab sib txawv, thiab yog siv nyob rau hauv kev kho mob ntawm lub raum anemia, chemotherapy-txog anemia thiab hematopoietic tswj mechanism kev tshawb fawb. |
| Protein purity (SDS-PAGE + HPLC, %) | Ntau dua lossis sib npaug li 95% / Ntau dua lossis sib npaug rau 98% |
| Qhov nruab nrab molecular hnyav | ~ 30.4 kDa (tom qab glycosylation) |
| Kev nthuav qhia system | Mammalian cell recombinant qhia |
Khoom Description
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Core Structure | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | Hloov kho hom | Qhov ntev (aa) |
| Epoetin zeta | Epoetin zeta; rhEPO zeta; EPO biosimilar; CAS Nr .: 604802-70-2 | Erythropoiesis nce qib, Renal anemia therapy, Recombinant glycoprotein, Chemotherapy anemia adjuvant, Hematopoietic regulation, Biosimilar | 165-amino acid ib leeg-chain glycoprotein, 4 qhov chaw glycosylation, hloov kho polysialylation | Glycoprotein, tsis muaj meej me me -molecule mis; raws li qhov tseeb batch MS | - | ~ 30400 (tom qab glycosylation) | N-glycosylation + O-glycosylation + sialylation | 165 (mature peptide) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv luv -Lub Sijhawm Cia Cia | Kua Stability | Khoom hmoov ruaj khov |
| PRO-EPO001 | hmoov dawb | Khaws hauv qab -20 degree, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab aliquoted. ** Txwv tsis pub txwv tsis pub rov qab khov-thaw thiab tshee tshee ** | Lyophilized formulation ruaj khov rau 2 xyoos ntawm 2-8℃kaw; reconstituted daws ruaj khov rau 2 lub lis piam ntawm 2-8 degree | Nyob ruaj khov rau 14 hnub ntawm 2-8℃nyob rau hauv cov xwm txheej tsis muaj menyuam. ** Tsis txhob khov kua, khov ua rau cov protein denaturation thiab aggregation **. Dissolve maj mam kom tsis txhob foaming. Muaj zog acid / puag, kub siab thiab mechanical shock tag nrho ua rau denaturation thiab inactivation | ruaj khov rau ntau tshaj 3 xyoos ntawm -20℃lyophilized & tiv thaiv los ntawm lub teeb |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov Cheeb Tsam Tshawb Fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PRO-EPO001 | Recombinant human EPO biosimilar uas txhawb nqa erythropoiesis thiab nce qib ntshav liab | Epoetin zeta yog tib neeg erythropoietin biosimilar recombinantly qhia nyob rau hauv mammalian hlwb. Nws cov amino acid ib ntus zoo ib yam rau tib neeg endogenous EPO, thiab glycosylation thiab sialylation hloov kho kom ntseeg tau hauv vivo ib nrab -lub neej thiab kev ua haujlwm lom neeg. Nws tshwj xeeb khi rau erythropoietin receptors (EPOR) ntawm cov pob txha pob txha erythroid progenitor hlwb, ua rau JAK2 / STAT5 teeb liab txoj hauv kev, txhawb kev loj hlob thiab kev sib txawv ntawm erythroid progenitors thiab inhibits apoptosis, thaum kawg nce peripheral liab cell suav thiab hemoglobin concentration. Clinically siv tsuas yog rau mob raum kab mob -induced raum anemia thiab chemotherapy-txog anemia, nws ua hauj lwm raws li ib tug tseem ceeb cov cuab yeej protein rau hematopoiesis regulation, erythrocyte txoj kev loj hlob thiab anemia pathogenesis tshawb fawb. | Kev tshawb fawb ntawm lub raum anemia, Tshuaj kho mob ntshav qab zib txoj kev tshawb fawb, Hematopoietic txoj kev loj hlob mechanism, Erythrocyte biology, Endocrine metabolism kev tshawb fawb, Recombinant protein tshuaj txoj kev loj hlob | Erythropoietin Receptor (EPOR); JAK2/STAT5 teeb liab txoj kev; Erythroid progenitor proliferation thiab txawv txoj kev |
Cim npe nrov: CAS 604802-70-2 epoetin zeta, Tuam Tshoj cas 604802-70-2 epoetin zeta manufacturers, lwm tus neeg, Hoobkas
