Shanghai Sonyt Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm mazdutide tfa hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo mazdutide tfa los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | Mazdutide TFA |
| Kev piav qhia | Mazdutide yog GLP-1/glucagon dual receptor co-agonist. Aib hloov pauv thiab sab - saw C18 fatty acid hloov kho ua tiav qhov kev ua haujlwm ntev metabolic. Siv rau hauv kev tshawb fawb txog kev rog, hom 2 mob ntshav qab zib thiab NASH. |
| Peptide purity (HPLC, %) | 95%/98%/99% |
| Theoretical dawb puag molecular hnyav | ~4568 Nws |
| Daim ntawv ntsev | TFA ntsev (TFA suav raws li qhov tseeb batch) |
Product Basic Information Table
| Khoom Lub Npe Lus Askiv | Product Abbreviation / Alias | Function Tags (comma-sib cais) | Puv Amino Acid Sequence | Molecular Formula | Exact Mass (Da) | Qhov nruab nrab MW (Da) | N-Terminal Hloov kho | C-Terminal Hloov kho | Qhov ntev (aa) |
| Mazdutide TFA | Mazdutide TFA; IBI362 TFA; GLP-1 / GCGR dual agonist | GLP-1/glucagon dual receptor co-agonist, Ntev- ua haujlwm metabolic peptide, kev tshawb fawb kev rog, kev tshawb fawb NASH, Albumin- khi ntev-ua yeeb yam, Glucolipid metabolism txhim kho | Histidine- -aminoisobutyric acid-glutamine-glycine-threonine-phenylalanine-threonine-serine-aspartic acid-tyrosine-serine-lysine-tyrosine-leucine-aspartic acid-serine-arginine-arginine-alanine{{18{1}} glutamines acid-phenylalanine-valine-glutamine-tryptophan-leucine-leucine-lysine(sab-chain conjugated -Glu-}AEEA linker diacid) -threoninamide | Nws txawv nrog TFA suav; Free Base theoretical C₂₁₀H₃₂₀N₄₄O₆₅ | - | ~4568 Da (dawb puag) | Dawb amine, nrog Aib unnatural amino acid | Amidation | 29 (ntxuav qaum qaum nrog sab- kev hloov kho sawb) |
Physicochemical Solubility & Cia Parameters
| Khoom Code | Qhov tshwm sim | Ntev - Lub Sij Hawm Cia Cov Cai | Luv -Lub Sijhawm Cia Cov Cai | Kua Stability | Khoom hmoov ruaj khov |
| PEB-MAZ001 | hmoov dawb | Khaws ntawm -20℃, nruj me ntsis tiv thaiv los ntawm lub teeb, kaw thiab qhuav, aliquoted; zam rov qab khov-thaw cycles thiab aggregation | Khoom hmoov ruaj khov rau 2 xyoos ntawm 2-8℃kaw thiab qhuav; cov kev daws teeb meem tau pom zoo kom npaj rau hauv DMSO | ruaj khov rau 72 h ntawm 4 degree; ruaj khov rau 6 lub hlis ntawm -80℃hauv aliquots; ruaj khov rau 1 lub hlis ntawm -20℃hauv aliquots. ** Cov dej tsis zoo solubility, DMSO yuav tsum tau **. Nyuaj mus rau aggregation thiab fibrillation thaum lub sij hawm cia; tsis txhob rov ua kom khov-thaw thiab ua kom muaj zog | ruaj khov rau 3 xyoos ntawm -20℃nyob rau hauv qhuav & tsaus ntuj |
Functional Description
| Khoom Code | Frontend Short Summary (rau cov npe tshawb nrhiav) | Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg | Cov cheeb tsam tshawb fawb (comma- cais) | Lub Hom Phiaj / Txoj Kev |
| PEB-MAZ001 | GLP-1/glucagon dual receptor co-agonist nrog synergistic poob phaus thiab txhim kho metabolic, siv rau kev rog rog thiab kev tshawb nrhiav kab mob metabolic | Mazdutide (txoj kev loj hlob code IBI362) yog ntev - ua haujlwm dual agonist ntawm GLP-1 receptor (GLP-1R) thiab glucagon receptor (GCGR). Aib amino acid hloov pauv txhim kho enzymatic stability, thiab C18 fatty diacid conjugated rau lysine sab saw ntawm -Glu thiab AEEA txuas txuas ntxiv nyob rau hauv vivo ib nrab-lub neej ntawm albumin khi, txhawb ib zaug - kev tswj hwm txhua lub lim tiam. Nws ib txhij ua haujlwm ob txoj hauv kev hauv metabolic: GLP-1 txoj hauv kev kho cov piam thaj- nyob ntawm kev txo qis thiab qab los noj mov; glucagon txoj kev txhawb nqa lub siab lipolysis thiab kev siv hluav taws xob. Kev sib koom ua ke ntawm ob lub hom phiaj ua tiav qhov kev poob phaus zoo dua thiab txhim kho metabolic rau tib lub hom phiaj agonists. Cov kev tshawb fawb ua ntej pom tau tias lub cev hnyav txo, txhim kho glucolipid metabolism thiab hepatic steatosis, ua rau nws yog ib qho cuab yeej tseem ceeb rau kev rog, hom 2 mob ntshav qab zib thiab NASH mechanism kev tshawb fawb, nrog rau kev txhim kho cov tshuaj peptide ob lub hom phiaj. | Kev tshawb fawb txog kev rog rog, Kev tshawb fawb txog ntshav qab zib hom 2, kev tshawb fawb NASH, kev tshawb fawb ntawm Glucolipid metabolism, Dual- phiaj xwm kev txhim kho tshuaj peptide, Kev tshawb fawb zog metabolism | GLP-1 Receptor (GLP-1R); Glucagon Receptor (GCGR); cAMP/PKA metabolic tswj txoj hauv kev; Hepatic lipolysis txoj kev |
Cim npe nrov: Tuam Tshoj mazdutide tfa manufacturers, lwm tus neeg, Hoobkas
