Shanghai Sunite Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov muag khoom ntawm fc131 cas 606968-52-9 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo fc131 cas 606968-52-9 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.
| Khoom npe | CAS: 606968-52-9; FC131 |
| Ib ntus | |
| Peb tsab ntawv ib ntus | |
| Peptide purity (HPLC, %) | 95%/98% |
| Cov mis mos molecular | C36H47N11O6 |
| Molecular Luj (Da) | 729.83 |
Product Basic Information Table
|
Khoom Lub Npe Lus Askiv |
Product Abbreviation / Alias |
Function Tags (comma-sib cais) |
Amino Acid Tag Nrho Lub Npe Sequence |
Molecular Formula |
Qhov hnyav Molecular (Da) |
Qhov Nruab Nrab Molecular Luj (Da) |
Terminal Hloov kho - N-terminus |
Terminal Hloov kho - C-terminus |
Qhov ntev (aa) |
|
FC 131 |
#FC131; CAS 606968-52-9; CXCR4 cyclic peptide antagonist; SDF-1 thaiv peptide; Chemokine receptor inhibitory peptide |
Kev xaiv CXCR4 chemokine receptor antagonist, SDF-1 / CXCR4 axis blockade, Tumor metastasis suppression, Stem cell migration regulation, HIV entry inhibition, Immune cell chemotaxis, GPCR peptide inhibitor, Inflammatory chemokine pathway |
Acetyl-Cys-Phe-Phe-Arg-CycloLeu-Thr-Trp-Cys-amide, intramolecular disulfide choj ntawm Cys1 & Cys9 |
C₅₆H₇₆N₁₆O₁₁S₂ |
1212.54 |
1213.41 |
Acetylation (Ac{0}}) |
C-terminal amidation (-NH₂) |
9 |
Physicochemical Solubility & Cia Parameters
|
Khoom Code |
Qhov tshwm sim |
Pom zoo Dissolution Protocol (los ntawm hnyav) |
Solubility Reference |
Tsis pom zoo Solvents |
Ntev - Lub Sij Hawm Cia Cov Cai |
Luv -Lub Sijhawm Cia Cov Cai |
Kua Stability |
Khoom hmoov ruaj khov |
Muaj feem xyuam pH Range |
|
PEB-FC131 |
Dawb lyophilized hmoov |
Dilute acetic acid, sterile ultrapure dej, nruab nrab PBS tsis; Me me hydrophobicity, glacial acetic acid txhim kho kev sib cais stability |
Ntau dua lossis sib npaug li 10 mg / mL (0.1% aqueous acetic acid) |
Tsis muaj dej ntshiab, alkanes, roj av ether organic solvents |
-20 degree, kaw thiab lub teeb- pov thawj, aliquot kom tsis txhob rov khov-thaw |
2 ~ 8 degree, siv nyob rau hauv 1 lub hlis, npaj tshiab thiab tsis muaj menyuam - lim nrog 0.22μm membrane |
ruaj khov rau 48 h ntawm 4 degree |
ruaj khov rau 3 xyoos ntawm -20 degree |
4.0~7.5 |
Functional Description
|
Khoom Code |
Frontend Short Summary (rau cov npe tshawb nrhiav) |
Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg |
Cov cheeb tsam tshawb fawb (comma- cais) |
Hom phiaj / Receptor |
|
PEB-FC131 |
FC131 yog ib qho kev xaiv zoo heev cyclic peptide CXCR4 antagonist, potently blocks endogenous ligand SDF-1 khi, suppresses qog metastasis, qia cell homing thiab HIV gp120-mediated viral nkag, canonical cuab tam antagonist rau chemokine txoj kev tshawb fawb |
FC131 yog ib qho engineered 9-amino-acid cyclic peptide incorporating unnatural cycloleucine residue. Kev hloov kho dual lub davhlau ya nyob twg (N-acetylation + C-amidation) ua ke nrog intramolecular disulfide daim ntawv cog lus ua kom muaj zog peptidase tsis kam thiab CXCR4 subtype selectivity, nrog nanomolar binding affinity rau CXCR4 thiab negligible off-target 1/CCR.X. Cov kev ua ub no tseem ceeb: 1. Chemokine axis blockade: Competitively inhibits SDF-1 khi rau CXCR4, tag nrho abrogates chemotactic migration ntawm lub cev tsis muaj zog, qog hlwb thiab hematopoietic qia hlwb; 2. Kev tshawb fawb oncological: Blocks qog cell invasion thiab nyob deb metastasis rau khoom qog metastasis & qog microenvironment qauv; 3. Antiviral daim ntawv thov: Tiv thaiv HIV gp120 co-receptor kev koom tes nrog CXCR4 kom txwv tsis pub nkag ntawm X4-tropic HIV hom; 4. Stem cell & inflammatory regulation: Modulates hematopoietic qia cell homeing and attenuates inflammatory immune cell infiltration in autoimmune disorders. Dav siv nyob rau hauv cov qog metastasis pharmacology, chemokine GPCR kev tshawb fawb, HIV virology, qia cell biology, tiv thaiv kab mob thiab tsom peptide tshuaj ntsuam xyuas |
Tumor metastasis pharmacology, Chemokine GPCR tshawb fawb, HIV kab mob nkag mechanism, Hematopoietic qia cell homing, Immune inflammatory regulation, autoimmune kab mob qauv, Peptide antagonist tshuaj txhim kho |
Chemokine Receptor CXCR4 (xaiv heev); Tsis muaj qhov cuam tshuam tseem ceeb -reactivity nrog CXCR1, CXCR2, CXCR7 |
Cov Ntaub Ntawv Tswj Xyuas Zoo
|
Khoom Code |
Purity Detection Method |
Molecular Weight Verification Method |
Kev Tswj Xyuas Qhov Ntsuas |
Impurity Control Standards |
|
PEB-FC131 |
HPLC High Performance Liquid Chromatography |
ESI-MS Mass Spectrometry |
Purity, Dej ntsiab lus, Acetate, Hnyav Hlau, Residual organic hnyav, Disulfide cyclization kev ncaj ncees |
Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5% |
SKU Specifications & Inventory Table
|
SKU Unique Code |
Yam khoom Code |
HPLC Purity |
Ntim Specification |
Lub Sijhawm Ua Haujlwm Ntau Lawm |
Customizable |
Optional Custom Modifications |
Cov ntaub ntawv suav nrog |
|
PEB-FC131-98-1 |
PEB-FC131 |
Ntau dua lossis sib npaug li 98% |
1mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation |
CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia |
|
PEB-FC131-98-5 |
PEB-FC131 |
Ntau dua lossis sib npaug li 98% |
5mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation |
CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia |
|
PEB-FC131-95-1 |
PEB-FC131 |
Ntau dua lossis sib npaug li 95% |
1mg ib |
5-10 hnub ua haujlwm |
Yog lawm |
Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation |
CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia |
Cim npe nrov: fc131 cas 606968-52-9, Tuam Tshoj fc131 cas 606968-52-9 manufacturers, lwm tus, Hoobkas
