Name: Tuam Tshoj Customized HS024 CAS 212370-59-7 Chaw tsim tshuaj paus, neeg muag khoom thiab Hoobkas - Lag luam wholesale Service - Sunite
Brand: Sunite
SKU: 311052783

Shanghai Sunite Biotechnology Co., Ltd. yog ib qho ntawm cov ua lag luam thiab cov neeg muag khoom ntawm hs024 cas 212370-59-7 hauv Suav teb, kuj txhawb kev pabcuam kev cai. Txais tos rau kev lag luam wholesale bulk zoo hs024 cas 212370-59-7 los ntawm peb lub hoobkas. Tiv tauj peb kom paub meej ntxiv.

Khoom npe	CAS: 212370-59-7; NAS
Ib ntus	Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide choj:Cys1-Cys9)
Peb tsab ntawv ib ntus
Peptide purity (HPLC, %)	95%/98%
Cov mis mos molecular	C58H79N19O10S2
Molecular Luj (Da)	1266.50

Product Basic Information Table

Khoom Lub Npe Lus Askiv	Product Abbreviation / Alias	Function Tags (comma-sib cais)	Amino Acid Tag Nrho Lub Npe Sequence	Molecular Formula	Qhov hnyav Molecular (Da)	Qhov Nruab Nrab Molecular Luj (Da)	Terminal Hloov kho - N-terminus	Terminal Hloov kho - C-terminus	Qhov ntev (aa)
SIB 024	#HS024; CAS 212370-59-7; Xaiv MC4R cyclic antagonist; Kev noj zaub mov stimulating peptide; Melanocortin receptor thaiv peptide	Kev xaiv MC4 receptor antagonist siab heev, pub tus cwj pwm stimulation, Melanocortin txoj hauv kev thaiv, Metabolic rog qauv, Antagonize MT-II / -MSH cov teebmeem plawv, GPCR peptide inhibitor, Kev tshawb nrhiav kev noj qab haus huv	Acetyl-Cys-Nle-Arg-Nws-D-2Nal-Arg-Trp-Gly-Cys-amide, Intramolecular disulfide choj ntawm Cys1 & Cys9	C₅₈H₇₉N₁₉O₁₀S₂	1265.52	1266.52	Acetylation (Ac{0}})	C-terminal amidation (-NH₂)	9

Physicochemical Solubility & Cia Parameters

Khoom Code	Qhov tshwm sim	Pom zoo Dissolution Protocol (los ntawm hnyav)	Solubility Reference	Tsis pom zoo Solvents	Ntev - Lub Sij Hawm Cia Cov Cai	Luv -Lub Sijhawm Cia Cov Cai	Kua Stability	Khoom hmoov ruaj khov	Muaj feem xyuam pH Range
PEB-HS024	Dawb lyophilized hmoov	Dilute acetic acid, sterile ultrapure dej, nruab nrab PBS tsis; Me me hydrophobicity, dilute acetic acid txhim kho kev sib cais stability	Ntau dua lossis sib npaug li 10 mg / mL (0.1% aqueous acetic acid)	Tsis muaj dej ntshiab, alkanes, roj av ether organic solvents	-20 degree, kaw thiab lub teeb- pov thawj, aliquot kom tsis txhob rov khov-thaw	2 ~ 8 degree, siv nyob rau hauv 1 lub hlis, npaj tshiab thiab tsis muaj menyuam - lim nrog 0.22μm membrane	ruaj khov rau 48 h ntawm 4 degree	ruaj khov rau 3 xyoos ntawm -20 degree	4.0~7.5

Functional Description

Khoom Code	Frontend Short Summary (rau cov npe tshawb nrhiav)	Cov lus piav qhia txog kev ua haujlwm lom neeg lom neeg	Cov cheeb tsam tshawb fawb (comma- cais)	Hom phiaj / Receptor
PEB-HS024	HS024 yog ib qho kev xaiv zoo heev cyclic peptide MC4 receptor antagonist, muaj zog tiv thaiv hauv nruab nrab melanocortin txoj hauv kev los txhawb kev noj zaub mov, siab thim rov qab hypotension & bradycardia induced los ntawm Melanotan II / -MSH, cov cuab yeej tseem ceeb antagonist rau qab los noj mov & metabolic txoj kev tshawb fawb	HS024 is a 9-amino-acid engineered cyclic peptide incorporating unnatural residues D-2-naphthylalanine and Norleucine. Dual terminal modification (N-acetylation + C-amidation) plus intramolecular disulfide bond drastically enhance peptidase resistance and receptor subtype selectivity. Receptor affinity ranking: MC4R (Ki=0.29 nM) >> MC5R > MC3R >>MC1R, nrog superior MC4 subtype selectivity piv rau lwm yam melanocortin antagonists. Core bioactivities: 1. Central appetite modulation: Intracerebroventricular tswj tshwj xeeb thaiv cov anorexic MC4 signaling nyob rau hauv hypothalamus kom robustly nce zaub mov noj nyob rau hauv nas / nas, thov rau anorexia, cachexia thiab lub zog metabolism qauv; 2. Cov kab mob plawv antagonism: ua kom muaj zog hypotension thiab bradycardia tshwm sim los ntawm -MSH los yog Melanotan II, cov cuab yeej zoo tshaj plaws los siv cov tshuaj melanocortin plawv plawv; 3. Metabolic GPCR tshawb fawb reagent: Ua haujlwm tshwj xeeb rau kev tswj tsis zoo rau MC4R, dav siv hauv kev rog, kev siv hluav taws xob, kev noj zaub mov hypothalamic thiab melanocortin SAR tshuaj ntsuam. Dav siv nyob rau hauv neuroendocrinology, pub coj cwj pwm science, metabolic rog rog, melanocortin GPCR kev tshawb fawb, cardiovascular peptide kev tswj thiab anorexia kab mob qauv	Neuroendocrinology, Kev tswj tus cwj pwm noj, Metabolic obesity pharmacology, Melanocortin GPCR kev tshawb fawb, Cardiovascular physiological mechanism, Anorexia kab mob qauv, Peptide antagonist tshuaj ntsuam xyuas	Melanocortin 4 Receptor MC4R (siab selectivity); Tsis muaj zog thib ob khi rau MC3R, MC5R, MC1R

Cov Ntaub Ntawv Tswj Xyuas Zoo

Khoom Code	Purity Detection Method	Molecular Weight Verification Method	Kev Tswj Xyuas Qhov Ntsuas	Impurity Control Standards
PEB-HS024	HPLC High Performance Liquid Chromatography	ESI-MS Mass Spectrometry	Purity, Dej ntsiab lus, Acetate, Hnyav Hlau, Residual organic hnyav, Disulfide cyclization kev ncaj ncees	Ib qho impurity Tsawg dua lossis sib npaug li 2%, Tag nrho cov impurities Tsawg dua lossis sib npaug li 5%

SKU Specifications & Inventory Table

SKU Unique Code	Yam khoom Code	HPLC Purity	Ntim Specification	Lub Sijhawm Ua Haujlwm Ntau Lawm	Customizable	Optional Custom Modifications	Cov ntaub ntawv suav nrog
PEB-HS024-98-1	PEB-HS024	Ntau dua lossis sib npaug li 98%	1mg ib	5-10 hnub ua haujlwm	Yog lawm	Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation	CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia
PEB-HS024-98-5	PEB-HS024	Ntau dua lossis sib npaug li 98%	5mg ib	5-10 hnub ua haujlwm	Yog lawm	Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation	CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia
PEB-HS024-95-1	PEB-HS024	Ntau dua lossis sib npaug li 95%	1mg ib	5-10 hnub ua haujlwm	Yog lawm	Biotin labeling, Fluorescent labeling, Isotope labeling, Unnatural amino acid site mutation	CoA, HPLC spectrum, MS huab hwm coj spectrum, Disulfide cyclization qhia qhia